Researchers from Gyeongsang National University investigate the anti-inflammatory effects of Rumex japonicus on Atopic dermatitis
Atopic dermatitis (eczema) is a multifactorial skin disease condition that makes your skin red and itchy. The disease can cause with complex interactions and is common in children and can be diagnosed at any age. Factors such as immunological abnormalities is responsible for onset of the condition, which is chronic and its severity increases with time. The common symptoms of the disease include dry, inflamed skin, intense pruritis, itching and skin hypersensitivity and can be accompanied by asthma or hay fever. Other systems include recurring rashes, persistent scratching, erythematous plaques, and small bumps that drip extracellular fluid.
Topical steroids, emollients, and oral anti-histamines are some of the current therapies that act as a first-line therapy. However, these therapies can also lead to side-effects in long-term use. Now, a team of researchers from Gyeongsang National University found that topical administration of Rumex japonicus inhibits the development of DNCB-induced atopic dermatitis skin lesions in mice. Mouse models of Atopic dermatitis can be used to perform detailed investigation of pathogenesis for allergic skin inflammation. Rumex japonicus is a perennial herb found in Japan, Korea, and China. Its biological properties and health benefits include anti-oxidant, anti-microbial, anti-tumor, anti-inflammatory, and anti-allergic effects. The herb also has potential clinical applications in skin disease due to its antioxidant activity. This can be attributed to the herb’s inhibition of T-helper 2 cell response.
The team found that the herb regulates the inhibition of Mitogen-activated protein kinase (MAPK) – involved in directing cellular responses to various stimuli— and NF-κB activation in TNF-α induced HaCaT cells and reduces the development of DNCB-induced atopic dermatitis lesions. The team concluded that topical administration of Rumex japonicus inhibits the development of DNCB-induced atopic dermatitis skin lesions in mice. Moreover, the herb also repressed the activation of ERK, p38, Akt and NF-κB in TNF-α-stimulated HaCaT cells, which may otherwise lead to development of many cancers. Overall, topical application of the herb can be an effective alternative therapy for the management of atopic dermatitis. The research was published in the journal MDPI Nutrients on March 7, 2019.
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