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Electrospinning Nanofibers for Therapeutics Delivery

Electrospinning Nanofibers for Therapeutics Delivery

Researchers from Korea National University of Transportation assessed recent advancements in the use of nanofibers for the delivery of therapeutic drugs, nucleic acids and growth factors

Nanotechnology is manipulation of matter on an atomic, molecular, and supramolecular scale and finds application in a wide range of sciences including biotechnology and biopharmaceuticals. Nanomaterials have excellent properties such as biocompatibility and minimal biological toxicity and find application in energy generation and storage, water and environmental treatment, and healthcare and biomedical engineering processes. Electrospinning is a fiber production method which uses electric force to draw charged threads of polymer solutions or polymer melts up to fiber diameters in the order of some hundred nanometers.

Electrospinning techniques can be classified into five categories: blend electrospinning; coaxial electrospinning; emulsion electrospinning; melt electrospinning; and gas jet electrospinning.  It offers advantages such as controllable diameter, easy handling, minimum consumption of solution, and cost effectiveness in large scale production of nanofibers. Now, a team of researchers from Korea National University of Transportation assessed current therapeutic delivery systems that use nanotechnology. The team also described the advantages of Nanomaterials in the field of biopharmaceuticals and biotechnology. Nanofibers are used in drug delivery as anticancer agents, antibiotics, Nonsteroidal anti-inflammatory drugs, and cardiovascular agents. Three different techniques can be used to form nanofibers: electrospinning, self-assembly, and phase separation.

Major advantages of electrospun nanofibers include biocompatibility, adhesiveness, sterile nature, and their efficiency in diverse applications. They are used in scaffold materials, wound dressing materials, drug delivery systems, filtration membranes, and catalysts for reduction, batteries and fuel cells. The team stressed on further development and research in the field of nanofibers. Enhanced nanofibers can facilitate various applications in biomedical therapeutic delivery, drug delivery, medical implants, and tissue engineering. The team also suggested further assessment of nanofiber technology for a wide range of applications. The research was published in the journal MDPI Nanomaterials on April 3, 2019.

Sagar Jagtap
Sagar Jagtap,

Kavya Borgaonkar
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