Advanced Bioresorbable Stent can Improve Stent Performance

Advanced Bioresorbable Stent can Improve Stent Performance

Biomedical engineers from 480 Biomedical, a Watertown, MA firm developed a self-expanding and 100% bioresorbable stent as strong as metal.

The study was published in Nature Materials research paper on December 23, 2017. After each heartbeat blood is passed through the arteries, which provides oxygen and nutrients to the body. Individuals suffering from diseases such as atherosclerosis show restricted arterial blood flow, which can limit the delivery of oxygen and nutrients. Stent are used to reestablish the flow by mechanically opening and re-expanding the damaged artery. However, most of the times stents are manufactured from non-degradable material, which can create complications leading to immune response and impair vessel healing.

Bioengineers have invented a new composite material for developing an elastic and bioresorbable stent, which is able to withstand arterial blood pressures. They produced a design made from commonly used FDA approved biomaterials. Initially they created a braided stent from poly L-lactide-co-glycolide (L-PLGA) fibers in a pattern that allowed bending and provided the underlying stent structure. To introduce elastic recoil strength, the mesh was spray coated with a novel thermoset polymer. After the elastomeric coating cures, it locks in the mesh at all points of intersection and allows retention to original shape after deformation.

Mechanical tests carried out on the new composite stents showed that they were as strong as metal stent benchmarks and could self-expand to 95% of their original diameter after being compressed inside a catheter. In vitro mechanical and degradation experiments combined with in vivo preclinical pig and sheep models guided the engineers in optimizing the polymer formulations. The engineers were able to tune the stent materials to find a ‘goldilocks zone’ in terms of elasticity, strength, and the rate of biodegradation. This resulted in excellent stent performance in a long-term sheep model.

According to Bioabsorbable Stents Market report published by Coherent Market Insights, conventionally the stents used are of metal type. New bioabsorbable stents made up of soluble can overcome the limitations of conventional materials. This device can have number of applications in treatment of tissue disease therapies. Stents could offer prominent treatment for patients suffering from peripheral artery disease, where conventional stents can fail due fracturing. Drugs aimed at improved healing could potentially be incorporated for controlled local release as these stent are biodegradable.

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