Artificial Sweetener to Intensify Symptoms of Crohn’s Disease

Artificial Sweetener to Intensify Symptoms of Crohns Disease

New research revealed that artificial sweeteners such as Splenda and products containing sucralose and digestible sweetener maltodextrin may increase the symptoms of Crohn’s disease

Crohn’s Disease is an inflammatory bowel disease of the digestive tract characterized by severe diarrhea, abdominal pain, bloody stools, fatigue, and weight loss. It can lead to life-threatening complications. According to Centers for Disease Control and Prevention, around 1.3% adults in the U.S. are suffering from Crohn’s disease. The study was published in the journal Inflammatory Bowel Diseases in March, 2018. Splenda is most common sugar substitutes, which is 600 times sweeter than sugar. Although it is very sweet, it has very few calories. The study was conduct on mice to observe the side effects of Splenda in people suffering from Crohn’s disease.
The mice was administrated with sucralose, which available by brand name Splenda and it was monitored for six weeks. It was observed that the sweetener increased the gut inflammation in mice with Crohn’s disease. The mice with a form of Crohn’s disease who drank water with Splenda had greater numbers of Proteobacteria or microbes that include pathogens such as E.coli and salmonella, in their intestines. Artificial sweetener was also reported to increase the activity of the enzyme myeloperoxidase in mice with the Crohn’s-like disease but not in mice without the condition. Myeloperoxidase attacks disease-causing microorganisms.

“Our results indicate that although Splenda may promote parallel microbiome alterations in CD-prone and healthy hosts, this did not result in elevated MPO levels in healthy mice, only CD-prone mice,” said the researchers involved in the study. “The consumption of sucralose/maltodextrin-containing foods might exacerbate MPO intestinal reactivity only in individuals with a pro-inflammatory predisposition, such as CD.” Consuming Splenda and other products that contain sucralose and the digestible sweetener maltodextrin should be avoided by people suffering from Crohn’s-like disease.

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