Binding Sperm with Precise Drug can Treat Gynecological Diseases
Delivering drugs specifically to cancer cells can be used to minimize treatment side effects. The new study reports that motility of sperm can be used for delivering cancer drugs directly to cervical tumors.
Scientists from American Chemical Society report on December 20, 2017 that they have successfully exploited the swimming power of sperm to transfer a cancer drug directly to a cervical tumor in the lab test. According to the Novel Drug Delivery System (NDDS) Market report published by Coherent Market Insights, novel ideas based on interdisciplinary approaches controlling the pharmacodynamics, immunogenicity, pharmacokinetics, bio-recognition, and efficiency of drug can aid in reducing the drug degradation, increasing availability of drugs, and prevent harmful side effects of drugs. There are lot of limitations involved in developing an effective way to target cancer cells with drugs such as drugs are unable to travel deeply through tissues and they can get diluted in body fluids or sidetracked and taken up by healthy organs.
To overcome this limitations, scientists from Mariana Medina-Sánchez and colleagues at the Leibniz Institute for Solid State and Materials Research Dresden used a sperm. The researchers loaded a common cancer drug doxorubicin into bovine sperm cells and outfitted them with tiny magnetic harnesses. Sperm-hybrid motor was guided to a lab-grown tumor of cervical cancer cells using magnetic field. When the harness arms pressed against the tumor the arms opened up releasing the sperm. The sperm was observed to travel into the tumor and fused its membrane with cancer cell and released the drug.
Drug-loaded sperm inactivated more than 80% of a cancerous ball while leaking very little of their payload en route. Further research is required to ensure the system could work in animals and eventually humans. Researchers believe that sperm motors can potentially treat cancer and other diseases in the female reproductive tract.
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