Biomaterial Scaffold to Culture T Cells for Immune Cell Therapy
Researchers at the Harvard Wyss Institute have developed a biomaterial scaffold that mimics the actions of antigen-presenting cells (APCs) in stimulating T cell growth and survival.
Anti-cancer T cell therapies involve culturing and modifying patient-specific T cells before administering them to a cancer patient, where they can attack and kill cancer cells. A major challenge with this technique lies in achieving sufficient T cell growth and survival in vitro to obtain a sufficient dose of T cells. The scaffold allowed the researchers to significantly expand T cell numbers in a dish, compared with existing culture methods and could bring T cell therapies, such as anti-cancer treatments closer to clinical reality.
Researchers at the Harvard Wyss Institute took inspiration from another immune cell type, the APC, which stimulates T cells to grow and survive during an immune response. The researchers designed a biomaterial scaffold that provides pro-survival and pro-growth biological cues to T cells, just like an APC in the body.
The research team used silica rods to develop scaffold. They loaded the rods with Interleukin-2, a protein produced by APCs that can enhance T cell survival and coated them using a lipid layer, to mimic the APC cell membrane. The team then incorporated antibodies to stimulate the T cells into the scaffold lipid membrane. “Our approach closely mimics how APCs present their stimulating cues to primary T cells on their outer membrane and how they release soluble factors that enhance the survival of the T cells,” said David Mooney, a researcher of the study.
According to CAR T Cell Therapy Market report published by Coherent Market Insights, CAR T cell is an innovative technique that involves removal of T Cells from patient’s blood before reinsertion using a genetically altered mechanism. Using the scaffolds, the researchers were able to expand T cells from mice and humans much faster than existing culture techniques and they confirmed that the expanded cells have clinical potential in a mouse lymphoma model.
You may be interested
Dental Implants Market to Develop Rapidly by 2018 – 2026Albert R - August 21, 2018
Dental Implants Market report 2018-2026 focuses on the major drivers and restraints for the key players. These research report also provides granular analysis of the market share,…
Latest Evolution of Geriatric Care Services Market Analysis 2026Albert R - August 21, 2018
Geriatric Care Services Market report 2018-2026 focuses on the major drivers and restraints for the key players. These research report also provides granular analysis of the market…