Diabetes Drug Treats Mice Suffering from Alzheimer’s disease
A drug developed for diabetes has been found to have potential treatment application for Alzheimer’s disease, according to a new study published in Science Daily on January 1, 2018.
Scientists found that memory loss significantly reversed in mice through a triple method of action of a drug developed for Type 2 diabetes.
Alzheimer’s disease is the most common cause of dementia and the numbers are expected to rise to two million people in the UK by 2051 according to Alzheimer’s Society, who part- funded the research.
Dr. Doug Brown, Director of Research and Development at Alzheimer’s Society, said: “With no new treatments in nearly 15 years, we need to find new ways of tackling Alzheimer’s. It’s imperative that we explore whether drugs developed to treat other conditions can benefit people with Alzheimer’s and other forms of dementia. This approach to research could make it much quicker to get promising new drugs to the people who need them.”
The benefits of these ‘triple agonist’ drugs have so far only been found in mice, however, further studies with existing diabetes drugs such as liraglutide have shown real promise for people with Alzheimer’s, so further development of this work is crucial.
The study used APP/PS1 mice, which are transgenic mice that express human mutated genes that cause Alzheimer’s. Those genes have been found in people who have a form of Alzheimer’s that can be inherited. Aged transgenic mice in the advanced stages of neurodegeneration were treated.
Increasing prevalence and incidence of Alzheimer disease is expected to increase demand for new therapies to treat the disease, as per anti-β-Alzheimer therapies market report published by Coherent Market Insights.
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