Difficult to Treat Cancer Cells can be Killed by Synthetic Lethality Nanoparticles
Researchers at the University of Iowa revealed on December 19, 2017, that they have developed a dual-action nanoparticles, which can selectively kill endometrial cancer cells also known as uterine serous carcinoma.
Chemotherapy is less effective as it only prevents cell division and do not inhibit existing cancerous cells. Cells with paused lifecycle are not prone to being eradicated by chemotherapy agents. The new nanoparticles approach overcomes this process. It stimulates the cancer cells to initiate mitosis and make them susceptible to chemotherapy that is suitably present.
The novel nanoparticle therapeutic approach combines paclitaxel, which is a common chemotherapy agent and nintedanib also known as BIBF 1120, which is a new cancer drug typically used to hinder angiogenesis. It was used to target cancer cells with a specific mutation in current treatments. The mutation that nintedanib screens is called Loss of Function p53 that prevents normal function of tumor cells and makes them less susceptible to chemotherapy.
“Basically, we are taking advantage of the tumor cells’ Achilles heel the Loss of Function mutation and then sweeping in and killing them with chemotherapy,” said Kareem Ebeid, a University of Iowa pharmacy student who was working on the study. “We call this a synthetically lethal situation because we are creating the right conditions for massive cell death.”
According to Nanoparticles Market report published by Coherent Market Insights, nanoparticle is currently a new area of research among many scientists as they can overcome the side effects of conventional cancer treatments using advance therapies involving nanoparticles. This approach was tested on endometrial cancer cells so far. It is expected to work on a variety of other cancers that show similar defensive properties.
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