Inhibiting Common Enzyme can Prolong Lifespan of Mammals
Inhibiting activities of RNA polymerase enzyme is found to extend the lifespan of flies and worms, which could have promising applications in anti-aging therapies.
RNA polymerase III (Pol III) is an essential enzyme required for cell growth, which is found in almost all cells of mammals. Pol III was inhibited using a variety of genetic techniques across several different model organisms including flies, worms, and yeast. Researchers have revealed a new target to extend the lifespan of mammals. According to Enzyme Market report published by Coherent Market Insights, Enzyme activity can be regulated by activators and inhibitors, which help increase and decrease the activity of enzymes, respectively. This property can be utilized in altering the functions of enzymes resulting into desired results.
The study was published in the journal Nature on December 4, 2017. Researchers from University College London, the University of Kent, and the University of Groningen examined the enzymes involved in aging. In early studies, immune-suppressing drug rapamycin was found to inhibit Pol III, which was observed to extend the lifespan of several animal models including mice. “Understandably, there’s a lot of hype around drugs that extend lifespan and promote healthy aging but very little is known about how they work, which is fundamental knowledge,” said study co-author Nazif Alic.
“We’ve uncovered a fundamental role for Pol III in adult flies and worms: its activity negatively impacts stem cell function, gut health and the animal’s survival,” said first author of study, Danny Filer. “When we inhibit its activity, we can improve all these. As Pol III has the same structure and function across species, we think its role in mammals, and humans, warrants investigation as it may lead to important therapies.” Further research is required to understand mode of action for inhibition of Pol III, which actually extends lifespan in animals. The study suggest that this novel mechanism could be a promising target for anti-aging therapies in near future.
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