Nanofiber-Based Biodegradable Bandages to Regenerate Damaged Tissue Cells

Researchers from National University of Science and Technology MISiS have developed biodegradable bandages to double growth of the damaged tissue cells

Research team have developed these bandages with nanofibers, which are composed of polycaprolactone altered with plasma components of human blood and a thin-film antibacterial composition. These therapeutic material have applications in regeneration of damaged tissues, which help in recovery from major burn damage. Regenerative medicines are designed for treatment of burn therapies. They are used to repair severely damaged skin due to burn, cut, fungal acne infection resulting into scar formation.     

Bandage is placed on the damaged area covering the normal skin tissue. The bandage is not replaced or removed throughout the healing process as it may cause pain to the patient. After a particular duration, biodegradable fibers dissolve into the skin making tissue regeneration faster. This process does not have any harmful side effects, as it is composed of harmless material.

Novel bandages developed by the team comprise multi-layers of multifunctional bioactive nanofilms and biodegradable fibers, which speed up regeneration of new tissue. Furthermore, the material is supplemented with antibacterial materials having antibiotics or silver nanoparticles for enhancing the healing process by increasing biological activity of the blood plasma proteins and hydrophilic groups.

Researchers are working on clinical trials in collaboration with Research Institute of Experimental and Clinical Medicine (Novosibirsk, Russia). In vitro studies have observed accelerated regeneration of tissues with application of this bandage. Furthermore, researchers believe to get promising results for in vivo testing of this material in near future.

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