Nanoparticle-Based Imaging can Monitor Metastasis Progression Throughout Body
Researchers at Rutgers University have developed a technique using nanoparticles, where nanoparticle spot and image small tumors throughout different organs in body.
The research was published in Nature Biomedical Engineering journal on December 19, 2017. Conventionally tumor detection is done using contrast-enhanced Magnetic Resonance Imaging (MRI), which can only detect tumors of a particular size. It leaves patients with smaller under diagnosed tumors preventing early treatment of cancers, which is the main disadvantage of this procedure.
The team of scientists developed a rare earth doped albumin encapsulated nanoparticles that emit short-wave infrared light that can be detected outside the body, at least of a mouse. These nanoparticle probes can attach to antibodies that target specific breast cancer cells and injected into mice in which the same breast cancer type has already metastasized. Using special light detectors team was able to spot the tumors by visualizing the short-wave infrared light emitted from the nanoprobes as they traveled to the different tumor sites.
According to Nanoparticles Market report published by Coherent Market Insights, introduction of nanoparticles into medical technologies have beneficial applications in imaging and diagnosis of cancer. “Cancer cells can lodge in different niches in the body, and the probe follows the spreading cells wherever they go,” said Vidya Ganapathy, one of the researcher at Rutgers. “You can treat the tumors intelligently because now you know the address of the cancer.”
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