New Skin Patch may help in Reducing Body Fat

New Skin Patch may help in Reducing Body Fat

New study revealed that novel type of skin patch may aid in reducing body fat and obesity by turning energy-storing white fat into energy-burning brown fat.

Brown fats are found in infants help to keep the body warm by burning energy. With increasing age, the amount of brown fat lessens and it is replaced with visceral white fats, according to the researchers of the study. “Our solution aims to use a person’s own body fats to burn more energy, which is a natural process in babies,” said Chen Peng, professor at Nanyang Technology University (NTU), Singapore. The study was published in the journal Small Methods on December 2017.

The novel type of skin patch contains micro-needles loaded with the drug Beta-3 adrenergic receptor agonist or another drug called thyroid hormone T3 triiodothyronine. After the patch is pressed into the skin for two minutes, micro-needles become embedded in the skin and detach from the patch, which can be removed later. Drug molecules slowly diffuse with degradation of micro-needles to the energy-storing white fat underneath the skin layer, turning them into energy-burning brown fats.

According to Skin Replacement Market report published by Coherent Market Insights, artificial skin facilitates generation of new skin on the affected area. Patch was observed to suppress weight gain in mice that were fed a high fat diet and reduce their fat mass by over 30%, over a period of four weeks. This findings could help to address the worldwide obesity problem without resorting to surgical operations or oral medications.

The treated mice also had significantly lower blood cholesterol and fatty acids levels compared to the untreated mice. “With the embedded micro-needles in the skin of the mice, the surrounding fats started browning in five days, which helped to increase the energy expenditure of the mice, leading to a reduction in body fat gain,” said Xu Chenjie, assistant professor at NTU.

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