New Study Finds Role of Ligands in Allergic Sensitization Phase

New Study Finds Role of Ligands in Allergic Sensitization Phase

Researchers from Universidad Politécnica de Madrid (UPM) have found that the ligands, compounds carried by allergens are actively involved in the allergic sensitization phase.

Researchers from Centre for Plant Biotechnology and Genomics (CBGP) have found that certain compounds carried by allergic proteins would be collaborating agents in the processes that trigger immune responses with the appearance of allergic symptoms. The study could help in developing preventive methods and effective treatments for allergies. The link was observed between proteins causing allergies despite being very similar to harmless allergens. Proteins which are common allergens are in pollen, mites, domestic animals, and food were identified by researchers.

However, the characteristics of proteins linked to allergens are not discovered yet. Pru p 3 protein responsible for the peach allergy was selected for the study. The team identified natural ligand of Pru p 3 as a compound formed by an alkaloid attached to a hydrocarbon tail. Results of the study revealed that the ligand is recognized by a type of cellular receptor called CD1d in the cell surface where the antigens appear. Substances able to provoke a response of the immune system to produce antibodies. The CD1d expressions are responsible for presenting lipid antigens activating cells of the immune system called iNKT. They produce an enormous amount of substances upon activation that cause the characteristic symptoms of allergic disorders.

Since many allergens transport diverse compounds, the discovery of Pru p 3 lipid-ligand as an adjuvant to promote allergic sensitization through its recognition by CD1d expressions open new horizons. The findings of the study can help in addressing allergies as they are serious public health issue due to their high social and economic costs. Around 150 million citizens in the European Union are allergic to specific substances.

According to Allergy Diagnostic and Treatment Market report published by Coherent Market Insights, allergy diagnostic services are used to identify the type of allergy and accordingly determine treatment regimen of allergic conditions. Thus, results of the study reveal the role of the collaborators needed of the ligands allowing to fully understand allergy causes for development of new methods of diagnosis and therapy.

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