New Study Reports Drug Molecules to Regulate Medically Important Protein

New Study Reports Drug Molecules to Regulate Medically Important-Protein

Study carried out by The Scripps Research Institute (TSRI) suggests that various pharmaceutical drugs can regulate signaling and protein expression linked to asthma, obesity, and type 2 diabetes.

The study was published in journal of National Academy of Sciences on December 2017. “The long-term goal is to use this knowledge to help discover new drugs,” said TSRI Professor David Millar, senior author of the study. The was focused on the β2 adrenergic receptor (β2AR), which a protein present on the cell membrane, where it binds external molecules and sends signals to the inside of the cell. β2AR belongs to a class of proteins called G protein-coupled receptors (GPCRs). There are more than 800 known human GPCRs associated with cardiovascular disorders, Parkinson’s disease, and Huntington’s. In fact, GPCRs are so crucial to disease that more than 35% of pharmaceuticals target these receptors.

As a part of the study, scientists incorporated β2AR in nanodiscs, which are small particles that mimic the native cell membrane but contain only a single receptor molecule. A section of the receptor was tagged with a fluorescent probe. The fluorescence intensity was monitored using microscope system. The probe lit up when the receptor was inactive and went dim when active giving the researchers a way to track activation in real time.

According to Cell Free Protein Expression Market report published by Coherent Market Insights, cell free protein expression uses translation machineries to extract the desired cells. It was found that the receptor naturally fluctuates between its active and inactive states in the absence of any drug. Tracking the behavior of an individual receptor molecules revealed these fluctuations for the first time. The findings explain role of β2AR exhibit signaling activity in the absence of any drug molecules and how different drugs can either stimulate or inhibit signaling.

You may be interested

Researchers Develop Novel Method to Fight Sepsis
Healthcare
Healthcare

Researchers Develop Novel Method to Fight Sepsis

Mohit Joshi - October 15, 2018

Researchers developed a novel method to fight sepsis, according to a study published on September 11, 2018. This study was conducted by the researchers at the Washington…

Digital Health Market Expansion to be Persistent During 2026
Business
Business

Digital Health Market Expansion to be Persistent During 2026

Albert R - October 12, 2018

"The Digital Health Market is expected to have a highly positive outlook for the next five years 2018-2026 according to a recently released Digital Health Market research…

Medical Grade Hydrogel Market Poised to Take Off by 2026
Business
Business

Medical Grade Hydrogel Market Poised to Take Off by 2026

Albert R - October 12, 2018

"The Medical Grade Hydrogel Market is expected to have a highly positive outlook for the next five years 2018-2026 according to a recently released Medical Grade Hydrogel…

Most from this category