New Study Reposts Novel Treatment for Type 2 Diabetes
New study reports that insulin sensitivity and glucose homeostatis can be restored by modulating sinus nerves.
The team led by Sílvia Vilares Conde from CEDOC-NOVA Medical School in collaboration with the pharmaceutical company Galvani Bioelectronics demonstrated through findings in rats that is possible to restore insulin sensitivity and glucose homeostasis by modulating electrically the carotid sinus nerve, which connects the carotid body with the brain. The study was is published in Diabetologia journal of the European Association for the Study of Diabetes on January 15, 2018.
The study performed by the research team on diabetic rats showed that the bilateral resection of the carotid sinus nerve, and therefore the abolishment of the connection between the carotid body and the brain, restore insulin sensitivity and glucose tolerance. However, the carotid body possess other physiological functions as the response to the lack of oxygen (hypoxia) or the adaptation to exercise, which can be disadvantage of this study. Team also described that the carotid body is over-activated in animal models of type 2 diabetes, suggesting that decreasing the activity of the organ could be a good therapeutic strategy.
Study demonstrated that is possible to maintain glucose homeostasis in animals in which electrodes have been implanted in the carotid sinus nerve and submitted to electrical modulation, without significant adverse effects. It has also been demonstrated that the electrical modulation is reversible. Researchers note that work will provide a long-term management of the disease with negligible adverse effects and interference with daily activities.
Type 2 diabetes is characterized by insulin resistance and by increased hepatic glucose production that culminates in hyperglycemia. Although a lot of efforts have been performed until the date none therapeutic induce long-term glycaemia control, being expected for the next decades a huge increase in the prevalence of the disease.
According to Non Invasive Diabetes Therapy Market report published by Coherent Market Insights, the influx of non-invasive therapy has reinforced the diabetes market in various ways ranging from economical cost incurred to patient treatment outcomes. Thus, this work gives hope to patients with metabolic diseases, as it brings a new approach for the management of type 2 diabetes.
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