New Study Reveals Health Benefits of Berry Pigment
New study from the University of Eastern Finland reported that anthocyanins, naturally occurring pigments in berries can improve the function of the sirtuin 6 enzyme in cancer cells
The regulation of sirtuin 6 enzyme in cancer cells could open up new possibilities for cancer treatment. The findings of the study were published in Scientific Reports in March 2018. Expression of genes controlling function functions of cell via key cellular signaling pathways is regulated by Sirtuins enzyme. Ageing causes changes in sirtuin function, and these changes contribute to the development of various diseases.
Sirtuin 6, or SIRT6 for short, is a less well-known enzyme that is also linked to glucose metabolism. Berries get their red, blue or purple colour from natural pigments, anthocyanins. “The most interesting results of our study relate to cyanidin, which is anthocyanin found abundantly in wild bilberry, blackcurrant and lingonberry,” said Minna Rahnasto-Rilla, Doctor of Pharmacy, the lead author of the article. Previous studies reported that
Furthermore, researchers designed a computer-based model to predict functions of different flavonoid compounds in plants for regulating the SIRT6 enzyme. The findings indicate that anthocyanins increase the activation of SIRT6, which may play a role in cancer pathogenesis. The study also lays a foundation for the development of new drugs that regulate SIRT6 function. The Finnish-American study included researchers from the University of Eastern Finland and the National Institute on Ageing in the US. The study was funded by the Academy of Finland, the Finnish Cultural Foundation, and the US National Institute of Health.
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