New Test can Detect Treatment Outcomes in Childhood Leukemia Patients

New Test can Detect Treatment Outcomes in Childhood Leukemia Patients

UC San Francisco scientists have developed a test to predict response of treatment to patients with juvenile myelomonocytic leukemia (JMML). It may also identify recovery of patients with less or no treatment. 

In a new study published on December 19, 2017 in Nature Communications, UCSF oncologists have discovered that epigenetic annotations of the genome chemical tags that affect the gene regulation can predict the response of JMML patients to treatment. Around 50 children in the U.S. below the age of four suffer from JMML each year. Bone marrow transplant is the only treatment option available with serious long-term side effects.

Using these tags as biomarkers, oncologists can make more informed treatment plans for these patients. However, the study also emphasizes that many patients are unlikely to ever benefit from currently available treatments and highlights a pressing need to develop new targeted therapies. “This data provides important information that will help clinicians decide how intensively and swiftly to treat their patients,” said senior author Mignon Loh, MD, a UCSF Benioff Chair of Children’s Health and the Deborah and Arthur Ablin Endowed Chair in Pediatric Molecular Oncology.

The researchers focused on one type of epigenetic tag called DNA methylation, which is known to have functions in controlling stem cell maturation in children and adults. The team studied genome-wide methylation levels in an initial group of 39 patients with JMML and then validated their results in an additional group of 40 patients treated in Germany. Stieglitz and Loh’s team examined methylation levels of patients using new test and they found that 14 of the 15 known cases of spontaneous recovery mapped closely onto the low-methylation group.

According to Cancer Biomarkers Market report published by Coherent Market Insights, cancer biomarkers can aid in early diagnosis and monitoring the response of treatment in patients with of leukemia. These findings suggest an requirement for further study to design and validate the new methylation test for analysis of JMML in children who could benefit from a this approach rather than to performing risky bone marrow transplants.

Request Sample copy of Cancer Biomarkers Market report @ https://www.coherentmarketinsights.com/insight/request-sample/175

You may be interested

Carbon Fiber Reinforced Plastics Market Positive long-term growth outlook 2018-2026
Business
Business

Carbon Fiber Reinforced Plastics Market Positive long-term growth outlook 2018-2026

Sayali Tribhuvan - June 21, 2018

Carbon Fiber Reinforced Plastics Market Report provides an analytical assessment of the prime challenges faced by this Market currently and in the coming years, which helps Market…

Smartphone Can Be Used As Car Key
Information Technology and Gadgets
Information Technology and Gadgets

Smartphone Can Be Used As Car Key

Sayali Tribhuvan - June 21, 2018

BMW exhibited their autonomous i3 electric car that can be summoned by phone at the Mobile World Congress (MWC), according to a report published on February 26,…

Scientists Discover 10,000 Black Holes at the Center of Galaxy
World News
World News

Scientists Discover 10,000 Black Holes at the Center of Galaxy

Sayali Tribhuvan - June 21, 2018

Scientists found 10,000 black holes at the center of Milky Way, according to a report published on April 4, 2018. The supermassive black hole at the center…

Most from this category