Novel Chemotherapy Delivery in India Hits Specific Target
An Indian scientist Dr Rajah Vijay Kumar on November 26, 2017, claimed a breakthrough in minimizing the side-effects of chemotherapy by discovering a novel drug delivery system that will target only cancer cells without harming healthy cells.
According to the Dr Rajah Vijay Kumar, the director and chief scientific officer at Centre for Advanced Research and Development (CARD), the patented system comprises whole-body device called Cellular Focused Resonance Nano-Permeabilisation or Cellforn, which can deliver chemotherapeutic molecules directly to the targeted cancer cells during chemotherapy. “The cargo is good, but the delivery is bad. That is where my team decided to intervene. Our work began in 2008,” Kumar said.
Although chemotherapy is effective cancer treatment, it has mild to severe adverse effects. Cellforn creates temporary nano pores, which receive drugs and allow delivery to the cell membrane of the cancer tissue identified with pre-treatment proton density evaluations.
“All drugs contain hydrogen atoms that bond with other molecules. The nucleus of the hydrogen atoms (containing only protons) in the drug are like bar magnets, they have specific alignments. Tissues too have protons that have the same alignment as the drug. Cellforn reverses the alignment of the hydrogen protons in the tumour tissue, spins it opposite to that of the drug molecule, attracting it to the sensitised tumour tissue,” Kumar explained.
Concentrations of target drugs are delivered based on their molecular weight. Cellforn also creates a temporary receptors or holes, which are induced by fast radio bursts (FRB) that is timed and delivered to target lesions. “Almost the entire drug payload is delivered to the tumour and minimal to the healthy tissue. Hence, there will be very little or no adverse side-effects,” Kumar said.
This precision-targeted drug delivery system is ready to hit the market. “I think we will go into production in nine months. Cellfornis a real breakthrough in targeted molecular delivery, and we are not just looking at cancer, but a wide range of other future possibilities,” Kumar added. Cellforn claims to make drugs 10 to 70 times more effective, as they can be highly localized and used in vivo and non-invasively. Major advantage of Cellforn is that it prevents the cancer tissue from developing immunity to the drug.
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