Novel Drug Can Repair Cavities and Aid in Tooth Regeneration

Novel-Drug-Can-Repair-Cavities-and-Aid-in-Tooth-Regeneration

New study reports that a drug used to treat Alzheimer’s disease might promote tooth repair by regenerating new tooth.

Tideglusib drug is developed to treat Alzheimer’s disease the drug also happens to promote the natural tooth regrowth mechanism, allowing tooth to repair cavities. A new discovery revealed that drug developed for Alzheimer’s patients might replace fillings for cavity repair. Tideglusib works by stimulating stem cells in the pulp of teeth, the source of new dentine. Dentine is the mineralized substance beneath tooth enamel that gets eaten away by tooth decay.

Teeth can naturally regenerate dentine without assistance, but only under certain circumstances. The pulp must be exposed through infection or trauma to prompt the manufacture of dentine. But even then, the tooth can only regrow a very thin layer naturally not enough to repair cavities caused by decay, which are generally deep. Tideglusib changes this outcome because it turns off the GSK-3 enzyme, which stops dentine from forming. As a part of the study, team inserted small, biodegradable sponges made of collagen soaked in Tideglusib into cavities. The sponges triggered dentine growth and within six weeks, the damage was repaired. It was observed that the collagen structure of the sponges melted away, leaving only the intact tooth.

Results of the study were so far observed in mouse teeth. According to Tooth Regeneration Market report published by Coherent Market Insights, though major advancements has been made in the field of dentistry, emotional connect with natural teeth and high attributes of natural teeth has led to attention on development of tooth regeneration. The study reveals new opportunities for the regeneration of tooth in patients with missing teeth. “Using a drug that has already been tested in clinical trials for Alzheimer’s disease provides a real opportunity to get this dental treatment quickly into clinics,” said Paul Sharpe, Professor London Dental Institute and lead author of the study.He added, “The simplicity of our approach makes it ideal as a clinical dental product for the natural treatment of large cavities, by providing both pulp protection and restoring dentine.”

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