Researchers Develop Novel Method to Fight Sepsis

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Researchers developed a novel method to fight sepsis, according to a study published on September 11, 2018.

This study was conducted by the researchers at the Washington State University. According to the study, stimuli-responsive nanoparticles can specifically target infections and simultaneously prevent spreading of bacteria, thereby reducing the inflammation. These nanoparticles contain antibiotic and anti-inflammatory agents that are released when infection is encountered in the body.

Researchers were trying to develop a method for fighting sepsis, which is a systemic inflammatory response that can cause organ failure. Zhenjia Wang, Pharmaceutical Sciences Assistant Professor, said, “This study not only proves a new drug delivery system but also may shift the current landscape in nanomedicine to biology-driven design of nanotherapeutics. This has the potential to improve the therapies of many more infectious diseases.”

A new nanoparticle was built by the researchers and it was coated with the molecules that blood vessels were found to release in response to infections. Due to this dressing, the nanoparticles become sensitive to the signature acidity of infection sites, and upon arrival at the site of an infection, the bacterial enzymes act as a trigger, thereby releasing the drugs.

The leading author of the paper said that the results of this study would help in the development of new drug formulations for the treatment of bacterial infections such as TB infection. Although the use of nanoparticle technology in medical practice is growing, it is the first time that a nanocarrier has been built for the delivery of two drugs. Moreover, it delivers these drugs only on encountering the infectious tissues. Furthermore, as the nanocarrier specifically targets the infection sites, less medicine is only needed and collateral damage to otherwise healthy tissues is limited with this method.

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