Researchers Found Precise Neuroprotective Approach to fix MS-Damaged Nerves
Increasing cholesterol synthesis in astrocytes of the spinal cord can be a new pathway to repair nerves that affect walking in patients suffering from multiple sclerosis.
Gene expression in specific regions of cell provide precise neuroprotective approach than conventional treatments for neurological diseases. Multiple sclerosis (MS) is an autoimmune and neurodegenerative disorder characterized by distinct disabilities affecting walking, vision, and cognition. Inflammation strips the myelin coating from nerve cell extensions called axons and connections at the ends of nerves called synapses are lost together disrupting signaling and eventually causing permanent disability depending on where this occurs.
Researchers from the University of California, Los Angeles proposed molecular mechanisms regarding neuroprotective treatments tailored for disability, which may be more effective than nonspecific treatments aiming to reduce a composite of different disabilities. The study was focused on gene expression of astrocytes that get activated in MS. The team assessed astrocytes in different regions of the brain and spinal cord, which have functions in walking and vision using a mouse model for MS. Gene expression changes between regions that correspond to different disabilities were compared.
Decrease in the expression of cholesterol synthesis genes was observed in the spinal cord. Cholesterol plays an important role in myelin synthesis, nerve coating, synapses, and nerve connections. It was observed that the loss of myelin and synapses due to inflammation results into decreasing cholesterol synthesis gene expression in astrocytes. MS mice was treated with a drug that increased expression in cholesterol synthesis genes and this resulted in improved walking ability.
According to Brain Health Devices Market report published by Coherent Market Insights, brain health devices are used in the treatment of neurological disorders such as MS and it can be used to monitor symptoms of disease for designing treatments plans for patients. This disability-specific discovery approach can be tailored to repair damage for each disability using neuroprotective treatments for neurodegenerative disorders.
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