Scientists Develop New Technique for Imprinting Biochips

Scientists devised a new biochip printing technique, allowing a large number of biomolecule probes to fit onto a single biochip, according to a study published on March 8, 2018. 

A team of researchers at the Advanced Science Research Center (ASRC) at the Graduate Center of the City University of New York developed a new method for preparing biochips. This can further help in the screening of biological changes associated with the development of several diseases, and other research areas.

The team combined various techniques namely the microfluidic technique and beam-pen lithography and photochemical surface reactions to create a new technique for biochip printing. In this method, the surface of a biochip is exposed to specific organic reagents, which is focused with a beam of light to hold the reagents together. The process enables repeated exposure of a single chip to the same or different factors, which imprints reactions onto different sections of the biochip each time.

The end result is a biochip with the potential to capacitate extensive number of probes, making this chip potentially more efficient and cost-effective than other chips.

“This is essentially a new nanoscale printer that allows us to imprint more complexity on the surface of biochip than any of the currently available commercial technologies. It will help us to gain much better understanding of how cells and biological pathways work.” said Adam Braunschweig, lead author of the study.

This development could enable printing on a several delicate materials, including glasses, metals, and lipids, without the requirement of a clean room as well as enable researchers to fit several biomolecules on a single biochip.

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