Scientists Suggest New Approach for the Treatment of Eczema
Scientists suggests a new approach to eczema that can activate a natural brake on this allergic attack, according to a study conducted on March 6, 2018.
Type 2 immune responses is the reason for inflammation of skin in a person suffering from eczema. These responses are caused by activated T helper 2 (TH2) cells and type 2 innate lymphoid cells (ILC2s), which are together referred to as effector cells. The allergic response is suppressed when type 2 responses are tempered by the regulatory T cells or Tregs. On observing an eczema lesion, it was observed that the number of Tregs remain unchanged. 5 percent of the T cells in the body and 50 percent of T cells in the skin are present in Tregs.
Two mouse models of eczema were analyzed by the researchers. Tregs from their skin and blood was purified and the genes were compared. They encoded one gene called the retinoid-related orphan receptor alpha (RORα). A genetic trick was used to remove RORα from Tregs and the researchers observed that allergic inflammation in the mouse models increased rapidly.
Raif Geha, chief of the Division of Immunology at Boston Children’s Hospital said, “The two kinds of immune cells are competing for TL1A. If Tregs don’t have this receptor, they can’t ‘see’ TL1A. Not only are they not activated, but more TL1A is available to activate the effector cells. So you have a double whammy.” Similar to mice, higher amounts of RORα in skin Tregs was documented by the researchers when human samples were tested.
Researchers are planning to explore the factors in the skin, which will drive RORα activity. This study would be beneficial to the allergy diagnostic and treatment market, as elaborated in the allergy diagnostic and treatment market report published by Coherent Market Insights.
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