Viral Vectors and Plasmid DNA Manufacturing Market – Global Industry Insights, Trends, Outlook, and Opportunity Analysis, 2017-2025

Viral-Vectors-and-Plasmid-DNA-Manufacturing-Market

Gene therapy and genetically modified therapies are promising treatment option, which includes introduction of a normal or functional copy of a gene in the defective cell. Gene therapy has capability to cure or prevent the progression of diseases, which include inherited disorders, cancers, cardiovascular diseases, neurological disorder, and infectious pathogen. There are number of systems showing efficient transfer of therapeutics gene into the target cells, which includes viral or non-viral vector. The most popular viral vectors used in gene therapy include adeno-associated viral (AAV), adenovirus, lentivirus, and retrovirus. Similarly, non-viral vectors mainly rely on delivery of plasmid DNA.

Request to download and view full ToC: https://www.coherentmarketinsights.com/ongoing-insight/toc/962

The inherent complexity of viral-based vectors is highly challengeable to develop quality vectors in terms of its physical size, formulation, delivery function, and cost. To overcome this, manufacturers opt for various approaches for the development of vectors, which include current good manufacturing practices (cGMP), expression systems, development of cell line culture, and cell culture system that are ideal for early-stage development of vectors in terms of simplicity, speed, and limited investment. This may boost the growth of viral vectors and plasmid DNA manufacturing market.

Growing number of gene therapy candidates with rapid progression of diseases is increasing the demand for vectors, which may stimulate the growth of viral vectors and plasmid DNA manufacturing market

Celsion Corporation announced final clinical and translational data on OVATION study at American Association for Cancer Research (AACR) in 2017. Celsion developed standard neoadjuvant chemotherapy with IL-12 DNA plasmid vector as a non-viral delivery system, which is formulated in nanoparticle – GEN-1. It is designed to treat patients with advance stage (III/IV) of ovarian cancers. The DNA-based immunotherapy GEN-1 plus IL-12 showed positive results in clinical trial phase 1b by causing sustained local production and secretion of IL-12 protein at tumor site.

Researchers – R. Jude Samulski from University of North Carolina and Anamaria C. Sanchez from University of Chile, 2017, developed a gene therapy to treat alcoholism by using short hairpin RNA (shRNA), which is delivered in livers using viral vector – adeno-associated viral (AAV). This is expected to help in prevention of liver enzyme expression that is mainly involved in metabolizing process of conversion of ethanol into acetate.

Moreover, Inovio pharmaceutical, 2017, developed synthetic plasmid DNA-based dMAb monoclonal antibody (mAb) technology for multiple influenza A and B virus strains. The dMAb is expected to trigger cells to activate desired antibodies by utilizing synthetic plasmid, which will encode sequences for cross-protective anti-influenza monoclonal antibodies. This approach is expected to allow rapid responses to unpredicted seasonal flu strains satisfying specific needs of the peoples, including geriatrics, pediatrics, and immune-compromised patients.

However, the major factor that is inhibiting the growth of viral vectors and plasmid DNA manufacturing market is high cost of gene therapies and possible mutagenesis.

Increasing funding in gene therapies is expected to fuel the growth of viral vectors and plasmid DNA manufacturing market

The growth of viral vectors and plasmid DNA manufacturing market is attributed to increased fund for gene therapy research, which is a major market driver. For instance, Alliance for Cancer Gene Therapy (ACGT) is a public charity foundation in the U.S, which funds for advancement in cancer gene therapies from laboratory to clinical trials.

The major key players in viral vectors and plasmid DNA manufacturing market includes Celsion Corporation, Inovio pharmaceutical, Lonza, Novasep, FinVector Vision Therapies, Cobra Biologics, Sigma-Aldrich Co. LLC, Biotech GmbH, and Kaneka and Corporation (Eurogentec).

You may be interested

First Flying Taxi Launched in the U.S.
Information Technology and Gadgets
Information Technology and Gadgets

First Flying Taxi Launched in the U.S.

Alex Mathew - February 16, 2018

Intel and Volocopter—a Germany-based startup unveiled its flying taxi at the CES in Las Vegas on January 10, 2018. Intel and Volocopter, in partnership, developed the VC200—more…

Fire TV Witnessed Inconvenience Due to Amazon-Google Feud
Information Technology and Gadgets
Information Technology and Gadgets

Fire TV Witnessed Inconvenience Due to Amazon-Google Feud

Alex Mathew - February 16, 2018

YouTube blocked the Silk web browser from displaying the TV-optimized interface normally on Fire TV, on January 22, 2018. It was confirmed that the TV interface was…

Bitcoin Value Reaches Half its Peak
Information Technology and Gadgets
Information Technology and Gadgets

Bitcoin Value Reaches Half its Peak

Alex Mathew - February 16, 2018

Bitcoin crashed to as low as US$ 9,500, falling below US$ 10,000 for the first time since November 2017 and neatly halving its December 19th peak of…

Most from this category