‘Body on Chip’ Device Examines Drug Effects on Organs before Clinical Trial
Engineers from Massachusetts Institute of Technology (MIT) developed technology called ‘body on a chip’ to detect side effects of new drugs on various organs of the body before testing them on humans
The advanced technology use microfluidic platform for linking engineered tissues of 10 body organs. The device can potentially test efficacy of drug to treat one organ. The study was published in the journal Scientific Reports on March 14, 2018, and it was funded by Defense Advanced Research Projects Agency funded the research. According to researchers, device process can accurately replicate human organ interactions over several weeks, which can help in development of antibody drugs and other immunotherapies.
The organ involved in the process include, liver, lung, gut, endometrium, brain, heart, pancreas, kidney, skin, and skeletal muscle. Preclinical testing on animals offer data regarding a drug’s safety and effectiveness, but it cannot reveal potential side effects on humans. “Some of these effects are really hard to predict from animal models because the situations that lead to them are idiosyncratic,” said study author Linda Griffith, a professor of biological engineering and mechanical engineering at MIT. “With our chip, you can distribute a drug and then look for the effects on other tissues, and measure the exposure and how it is metabolized.”
Along with this, MIT researchers developed a new technology named physiome on a chip, which allows tissues to grow and interact with each other by mimicking the functions of human organs. It also allows fluid to flow in and out and a way to manipulate functions inside the chip. An open allows manipulation of system and removal of samples. As results of study, drug was successfully delivered to gastrointestinal tissue, mimicking oral ingestion of a drug. Team monitored the pathway for transportation of drug along with its effects on different tissues. The institute is currently working on developing a model system for Parkinson’s disease that includes brain, liver, and gastrointestinal tissue.
You may be interested
Tricks Used by Insurance Companies to Deny Legit Claimsmedia - December 10, 2018
Health insurance companies strategize in making more and more money by paying out as little as possible. Many times, they deny legitimate claims which are covered under…
New Study Suggests Typical Use of Sunscreens Offers Less Sun ProtectionMohit Joshi - December 10, 2018
Researchers from King's College London revealed that use of sunscreen offers less than half the sun protection as users apply more thinly than manufacturers recommend. In a…
Tamoxifen Market: Segmented by Application and Geography Trends, Growth and Forecasts 2026Albert R - December 10, 2018
Tamoxifen Market report is a research database spread across various pages with multiple tables and figures in it. The research covers a valuable source of perceptive information…