Broccoli Coupled with Reprogrammed Gut Bacteria can Battle against Cancer
New study reveals that with the help of smart genetic modification consuming broccoli daily could actively help body to battle cancer.
Researchers at the National University of Singapore (NUS) developed a new treatment for colorectal cancer, which is one of the most common cancers worldwide. Researchers aim to transform vegetables and a bacteria mixture into a targeted system, specially designed to seek out and destroy colorectal cancer cells throughout the body. A study was published in Journal Nature Biomedical Engineering on January 2018.
“Our primary goal was to make use of what we already have in our body for disease prevention and treatment; basically reprogramming gut microbes that live with us to convert food into drugs on demand,” said Professor Matthew Wook Chang, one of the researchers on the project. Gut microbes were reprogrammed to harness dietary vegetable compounds to target colorectal cancer. These gut microbes specifically recognize and bind onto the colorectal cancer cell surface. The microbes use enzymatic conversion to unlock the latent anticancer properties of the plant-derived compounds to inhibit cancer cell growth and cause the cancer cells to self-destruct.
As a part of the study, mixture of engineered probiotics and broccoli extract was shown to be capable of killing over 95% of colorectal cancer cells. “We hope that these microbes could be used as a form of supplement drink or pills that could be taken on a weekly basis for people above a certain age or at risk of colorectal cancer,” Chang said. “The ingested microbes will screen the gut for any abnormal cells and naturally clear them with the help of a vegetable diet. Another application is to have these cells used in post-operative care where patients can take these microbes to help eliminate any remnant cancerous tissues after a surgery to remove the tumor.”
According to Recombinant DNA Technology Market report published by Coherent Market Insights, Recombinant DNA technology (rDNA) helps to identify the gene function and its regulation in normal and pathogenic condition. The combination of probiotics and vegetables reduced tumor numbers by 75%in mice suffering from colorectal cancer. Those tumors which did appear were three times smaller than those found in mice which hadn’t undergone the treatment.
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