Magnetically Applied MicroRNAs Could Relieve Constipation in a Day

New tools could help patients with the side effect of opioid use such as constipation and aging. The article was published in the American Journal of Physiology-Gastrointestinal and Liver Physiology in January, 2018. 

Using a new technique to deliver gene-therapy-like intervention researchers at Thomas Jefferson University increased or decreased the muscle tone of the anal sphincter in appropriate animal models. These studies could have implications in treating constipation or incontinence. Constipation is an underestimated and debilitating medical issue related to the opioid epidemic. Both constipation and incontinence have associated with the problems related to the regulation of a ring of smooth muscle around the anal opening termed, the internal anal sphincter.

Researchers used microRNAs to regulate the target gene RhoA/ROCK to strengthen or weaken the muscle tone of the sphincter. The investigators localized microRNAs to the ring of muscle by first injecting the microRNAs mixed with micro metal beads and then kept them localized to the sphincter with a magnet.

According to Opioid Induced Constipation Treatment Market report published by Coherent Market Insights, opioid-induced constipation is one of the most prevalent adverse effects connected with long-time use of opioids, which have a detrimental impact on the quality of life of the individual. This study reports innovative yet simple approach, which is more effective at keeping the microRNAs in the right place than injecting the microRNAs alone. However, further research is required to demonstrate whether the same principals hold true in humans without side effects.

You may be interested

Oncology Biosimilars Market – Trends Research & Projections for 2017-2025
Healthcare
Healthcare

Oncology Biosimilars Market – Trends Research & Projections for 2017-2025

Albert R - February 21, 2018

Biosimilar is a biological product that resembles a reference product and is not difference from the already approved reference product. These are relatively cheaper than branded or…

Tubeless Insulin Pump Market – Global Industry Insights, Trends, Opportunity Analysis 2017-2025
Healthcare
Healthcare

Tubeless Insulin Pump Market – Global Industry Insights, Trends, Opportunity Analysis 2017-2025

Albert R - February 20, 2018

Tubeless insulin pump is a portable pump, which is effective in controlling blood glucose level. Advancements in technologies of insulin pumps, which reduce the need for daily…

Cervical Pillow Market – Global Industry Insights, Outlook, Opportunity Analysis, 2017-2025
Healthcare
Healthcare

Cervical Pillow Market – Global Industry Insights, Outlook, Opportunity Analysis, 2017-2025

Albert R - February 20, 2018

Cervical pillow is used to support the natural position of the head and neck while sleeping with different positions such as supine lying positions or side sleeping…

Most from this category