New Drug Could Reverse Effects of Excessive Drinking

New drug named as tandospirone can effectively aid in reversing harmful effects caused by heavy smoking on brain.

According to the research published in the journal Scientific Reports, Tandospirone drug selectively acts on a serotonin receptor. The researchers also showed that the drug was effective in inhibiting anxiety-like behaviors associated with heavy alcohol intake accompanied by a significant decrease in binge-like alcohol intake.

As a part of study, mice was supplemented with drug for two weeks. Reversed effects was observed after15 weeks of binge-like alcohol consumption on neurogenesis – the ability of the brain to grow and replace neurons. This is the first time tandospirone has been shown to reverse the deficit in brain neurogenesis induced by heavy alcohol consumption. “This is a novel discovery that tandospirone can reverse the deficit in neurogenesis caused by alcohol,” said Professor Selena Bartlett from the Queensland University of Technology in Australia. “This opens the way to look at if neurogenesis is associated with other substance-abuse deficits, such as in memory and learning, and whether this compound can reverse these,” she said.

According to the researchers, this drug is relatively new and available only in China and Japan. It is commonly used in this region and it is proved to be to be highly effective in treating general anxiety with limited adverse effects. The researchers are working on developing strategies for alcohol abuse and addiction, which is characterized by extended periods of heavy alcohol use, binges and abstinence, and anxiety and depression resulting into relapse. “This is not just another drug that shows promise in helping to reduce binge drinking,” Bartlett said. “While it could possibly have that effect, it might be able to help reboot the brain and reverse the deficits the alcohol abuse causes,” she said.

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