Study Reveals Estrogen Treatment can have Positive Effects on MS Patients

Estrogen Treatment

Researchers from University of California, Los Angeles revealed that the hormone estrogen can protects against central nervous system degradation in patients suffering from multiple sclerosis (MS).

The researchers found that estrogen treatment can have positive effects on brain cells called oligodendrocytes, which can provide protection from Multiple sclerosis. MS occurs when inflammatory immune cells destroy the myelin sheath surrounding nerve processes called axons, which results in to loss of protective insulation leading to disruption of electrical communication between nerve cells. Study reports that estrogen protected the brain from damage by activating a protein called estrogen receptor beta (ERb).

ERb was genetically eliminated in either immune cells of the brain or in oligodendrocytes, the cells that make the myelin sheath, as a way of making cells unresponsive to estrogen during the MS in mice. Mice was treated without or with ERb in these cells to check if disease protection was lost or not. Results showed that the estrogen-like treatment was acting on both immune cells of the brain as well as on oligodendrocytes, together resulting in repair of myelin and less disability.

According to Multiple Myeloma Drugs Market report published by Coherent Market Insights, apart from chemotherapy drugs, estrogen-like compound can combat MS via complementary effects on two distinct cell types. Researchers are working on developing a next-generation estrogen-like compound with robust biochemical effects on oligodendrocytes and immune cells in the brain, which can help to treat patients with MS.

You may be interested

Smart Nanotechnology Enlivens Wooden Ships and Artifacts
Business
Business

Smart Nanotechnology Enlivens Wooden Ships and Artifacts

Mohit Joshi - January 28, 2019

Scientists developed an innovative approach using ‘smart’ nanocomposites to conserve 16th-century British warship, the Mary Rose, and its artifacts. Shipwrecks are preserved in sediments under cold water,…

Researchers Discovered New Properties of Ferroelectric Crystal
Business
Business

Researchers Discovered New Properties of Ferroelectric Crystal

Mohit Joshi - January 25, 2019

Researchers discovered new properties of ferroelectric crystal, according to a study published on July 10, 2018. This study was conducted by a team of researchers from China.…

Researchers Develop Novel Antibody to Knockdown of Protein in Vertebrates
Healthcare
Healthcare

Researchers Develop Novel Antibody to Knockdown of Protein in Vertebrates

Mohit Joshi - January 24, 2019

Researchers from Technische Universität Dresden developed a synthetic antibody that improves functional analysis of proteins. A research led by Dr. Jörg Mansfeld of the Biotechnology Center of…

Most from this category