Study Reveals Estrogen Treatment can have Positive Effects on MS Patients
Researchers from University of California, Los Angeles revealed that the hormone estrogen can protects against central nervous system degradation in patients suffering from multiple sclerosis (MS).
The researchers found that estrogen treatment can have positive effects on brain cells called oligodendrocytes, which can provide protection from Multiple sclerosis. MS occurs when inflammatory immune cells destroy the myelin sheath surrounding nerve processes called axons, which results in to loss of protective insulation leading to disruption of electrical communication between nerve cells. Study reports that estrogen protected the brain from damage by activating a protein called estrogen receptor beta (ERb).
ERb was genetically eliminated in either immune cells of the brain or in oligodendrocytes, the cells that make the myelin sheath, as a way of making cells unresponsive to estrogen during the MS in mice. Mice was treated without or with ERb in these cells to check if disease protection was lost or not. Results showed that the estrogen-like treatment was acting on both immune cells of the brain as well as on oligodendrocytes, together resulting in repair of myelin and less disability.
According to Multiple Myeloma Drugs Market report published by Coherent Market Insights, apart from chemotherapy drugs, estrogen-like compound can combat MS via complementary effects on two distinct cell types. Researchers are working on developing a next-generation estrogen-like compound with robust biochemical effects on oligodendrocytes and immune cells in the brain, which can help to treat patients with MS.
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